Currently, we have several projects regarding modelling aetiology of HCC using adult human liver derived organoids. We focus on two aetiologies: Viral infection( Hepatitis B virus) and metabolic dysfunction-associated steatotic liver disease (MASLD). In general, we aim to identify molecular mechanisms underlying HCC development associated with different etiologies, facilitate the identification of early biomarkers, and potentially reveal novel therapeutic targets.

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Development of novel research technology for the detection of HBV DNA and RNA in HBV infected organoids

People working on the project

Zora Sinay, MSc – PhD Candidate
Xingyu Fan, MSc – PhD Candidate

Modeling HBV infection using human hepatocyte organoids to investigate the molecular mechanisms underlying HBV-mediated hepatocarcinogenesis

People working on the project

Xingyu Fan, MSc – PhD Candidate

Modeling early-stage MASLD using differentiated adult human liver organoids to investigate the underlying molecular mechanisms and identify potential therapeutic targets.

People working on the project

Xingyu Fan, MSc – PhD Candidate
Bram Torenvliet, MSc – PhD Candidate